deskthority

Not exactly a traditional mouse, but I much prefer and have attached to all my computers a track ball. Doesn't require desk space for moving the device and is quite precise without the inherent wrist strain that traditional mice are associated with.

Used to try to try opposite thumb depending on which hand the next character required. That took a bit of practice but once I built a grid layout planck keyboard, it is left thumb shift, righ thumb backspace. That took almost no practice at all to get used to, it felt to natural -- plus, I guess I'm...

Don't know about best, but I switched to the logitech trackman eons ago. Use it with all my desktop systems.

http://www.logitech.com/en-us/product/trackman-marble