Here's my opinion:
The current way of having 1/2 key staggering for bottom to middle row and 1/4 from middle to top is just stupid.
Considering how I hold my hands I think 1/2 key staggering might actually be better than 1/4.
While we're at it. Why the fuckedy fucking fuck are keys getting smaller to the top? Look at this ANSI layout:

Your hands point toward the top middle of the keyboard but the keys are arranged like they are pointing outward. What is up with that? One of these days we should actually try the suggestion from the hypermicro thread and use a board upside down.

Edit: Removed the option to vote for split keyboards with matrix layout. We all know that's better but some people seem to prefer their boards in one piece.
